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Standing amid its congenial clutter, a child visitor can easily grasp how it is, as Miyazaki writes in the museums catalogue, that imagination and premonition and sketches and partial images can become the core of a film. Indeed, Spirited Away, the story of a sullen ten-year-old girl who finds herself transported from an abandoned theme park into a ravishing spirit world, was inspired in part by Miyazakis own visit to a peculiar outdoor attractiona Tokyo museum where old Japanese buildings, including a splendid bathhouse, had been carted from their original locations

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In these mice, insufficient PDGFR/PI3K/AKT activation is primarily due to reduced PRKN expression ( 5.2 Mitochondrial dynamics in IPF Alveolar epithelial cells are important therapeutic cells in the pathogenesis of IPF, and researchers have observed enlarged mitochondria in such cells in IPF ( 5.3 Mitochondrial biogenesis in IPF Repeated damage to type II alveolar epithelial cells is an important cause of pulmonary fibrosis, but repeated damage to such cells is not necessary in the progression of pulmonary fibrosis ( 6 Conclusion As research into mitochondrial quality control has progressed, researchers have identified important roles in disease development, particularly in neurodegenerative diseases such as Parkinsons and cardiovascular disease, which have proved worth exploring ( Statements Author contributions XH and GL: funding acquisition, conceptualization and supervision

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The main pharmacological treatments available for smoking cessation are the following: nicotine replacement therapy (NRT), varenicline, bupropion and cytisine (see Table 2) [19]